Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated for article-operative management in pediatric sufferers younger than eighteen a long time of age following tonsillectomy and/or adenoidectomy [see Contraindications (four)]. Avoid using Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 yrs of age who produce other hazard things that could raise their sensitivity for the respiratory depressant consequences of codeine Until the benefits outweigh the challenges.
DailyMed will produce notification of updates and additions to Drug Label information currently proven on This web site via its RSS feed.
Get this drugs only as directed by your health practitioner. Tend not to get additional of it, tend not to just take it additional usually, and don't just take it for a longer time than your medical professional purchased. If too much of the medicine is taken for a long period, it may come to be behavior-forming and trigger psychological or physical dependence.
Doc site views are up to date periodically each day and so are cumulative counts for this document. Counts are matter to sampling, reprocessing and revision (up or down) during the day.
Impaired secretion from sweat glands following poisonous doses of prescription drugs with anticholinergic Unintended effects may possibly predispose to hyperthermia.
Promethazine Promethazine is a phenothiazine by-product, which differs structurally with the antipsychotic phenothiazines by the existence of a branched aspect chain and no ring substitution.
Unresponsive Cough The dosage of Promethazine with Codeine Oral Solution should not be enhanced if cough fails to respond; an unresponsive cough must be reevaluated in 5 days or sooner for probable fundamental pathology, which include international human body or decrease respiratory tract disease [ see Dosage and Administration ( two.three) ].
Labor or Shipping and delivery Opioids cross the placenta and may develop respiratory despair and psycho-physiologic results in neonates. An opioid antagonist, for instance naloxone, should be available for reversal of opioid-induced respiratory melancholy in the neonate. Opioids, like Promethazine with Codeine Oral Solution, can prolong labor by steps which briefly lessen the power, length, and frequency of uterine contractions.
Do not utilize a house teaspoon to measure your medicine. You could unintentionally take an excessive amount of. It is possible to check with your pharmacist for that measuring product you ought to use and the way to measure the proper dose.
The opioid antagonists, naloxone and nalmefene, are precise antidotes for respiratory depression resulting from opioid overdose. For clinically sizeable respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist shouldn't be administered from read more the absence of clinically sizeable respiratory depression. Because the length of opioid reversal is predicted to generally be lower than the length of motion of codeine in Promethazine with Codeine Oral Solution, cautiously observe the patient right up until spontaneous respiration is reliably reestablished.
Speak to community point out Experienced licensing board or point out managed substances authority for information on how to avoid and detect abuse or diversion of this merchandise.
Do not flush medicines down the bathroom or pour them right into a drain Until instructed to take action. Properly discard this item when it truly is expired or no more desired. Consult your pharmacist or neighborhood waste disposal firm.
The dosage of Promethazine HCl and Codeine Phosphate Oral Solution should not be improved if cough fails to respond; an unresponsive cough ought to be reevaluated in five times or faster for probable fundamental pathology, which include overseas overall body or decrease respiratory tract disorder [see Dosage and Administration (2.3)].
Codeine may lead to miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are usually not pathognomonic (eg., pontine lesions of hemorrhagic or ischemic origin could deliver comparable results). Marked mydriasis rather than miosis could be found with hypoxia in overdose scenarios [see